Passive Immunotherapy (Monoclonal Antibodies)
Monoclonal antibodies mimic the antibodies your body naturally produces as part of your immune system’s response to germs, vaccines, and other invaders.
When a monoclonal antibody attaches to a cancer cell, it makes the cancer cell more visible to the immune system. The immune system attacks foreign invaders in your body, but it doesn’t always recognize cancer cells as enemies.
A monoclonal antibody can be directed to attach to certain parts of a cancer cell. In this way, the antibody marks the cancer cell and makes it easier for the immune system to find.
MONOCLONAL ANTIBODY THERAPY (MAB)
Monoclonal antibody therapy (MAB), the most widely used form of cancer immunotherapy today, is a form of passive immunotherapy. Monoclonal antibodies often do not require the patient’s immune system to take an active role in fighting the cancer.
Monoclonal antibodies are considered targeted therapy. Targeted immunotherapy is therapy directed to a single target on a cancer cell, usually an antigen or a receptor site on the cancer cell, or it is directed at a cancer specific enzyme or protein.
Monoclonal antibodies bind only to cancer cell-surface specific antigens. When an antibody recognizes the antigen against which it is directed, they fit together like two pieces of a puzzle setting off a cascade of events leading to tumor cell death.
Passive immunotherapies are comprised of antibodies or other immune system components that are made outside of the body (i.e. in the laboratory) and administered to patients to provide immunity against a disease, or to help them fight off an infection.
Passive immunotherapies do not stimulate a patient’s immune system to “actively” respond to a disease in the way a vaccine does.
Read more….Passive Immunotherapy
http://www.cel-sci.com/passive_immunotherapy.html
http://cancer.disease.com/Treatment/Immunotherapy/active-passive-immunotherapy.html
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